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Bayern Munich secured a 2-1 win over RSC Anderlecht at the Constant Vanden Stock Stadium to put themselves nine points ahead of third placed Celtic, while the Belgian side remain bottom of Group B.
The Bundesliga side showed their cutting edge to make Anderlecht rue their missed opportunities as Robert Lewandowski netted a simple tap-in for his second goal in this season's Champions League.
The Belgian side equalised with their first goal of this season's Champions League through captain Sofiane Hanni's close range finish 63 minutes in, but Corentin Tolisso's header 13 minutes from time ensured Anderlecht stay bottom of Group B with no points.
Anderlecht boss Hein Vanhaezebrouck made six changes following their 2-1 win at Mouscron at the weekend as Frank Boeckx, Josué Sá, Henry Onyekuru, Massimo Bruno, Nicolae Stanciu and Hamdi Harbaoui made way for Matz Sels, Dennis Appiah, Kara Mbodji, Pieter Gerkens, Łukasz Teodorczyk and Hanni.
Jupp Heynckes made four changes to the side that beat Augsburg 3-0 on Saturday with Juan Bernat, Rafinha, Javi Martínez, James Rodríguez and Mats Hummels replaced by Tolisso, Thiago, Jerome Boateng, Marco Friedl and Sebastian Rudy.
Anderlecht got off to a flying start and should have found themselves in front after just eight minutes when Teodorczyk went clean through against Bayern keeper Sven Ulreich, only to see his effort blocked by the German.
The Belgian side continued to create chances early on as Hanni was the next to see an effort from the edge of the area kept out by Ulreich, who has been standing in for the injured Manuel Neuer this season.
Teodorcyk wasted the half's biggest chance on half-an-hour as he found himself in behind the Bayern defence thanks to Hanni's lofted ball, but the Polish forward fired wide to the relief of Ulreich.
Bayern's only real chance of the opening 45 came shortly afterwards as Lewandowski saw his goal-bound shot blocked following a scramble in the Anderlecht penalty area, moments before Teodorczyk headed Appiah's cross wide from 10 yards out.
The Polish striker wasted yet another chance five minutes before the break to spare Tolisso's blushes, the Frenchman playing a lobbed ball in behind his own defence to send Teodorczyk through but Ulreich was there once again to block the shot.